The combination of tumor burden mutation (TBM) and immune cell infiltration (ICI) scoring yields an accurate predictor of survival in bladder cancer, according to a study published in Frontiers in Genetics.

Researchers analyzed 569 common gene expressions using the Cancer Genome Atlas and Gene Expression Omnibus expression databases and assessed for differentially expressed genes. They used principal-component analysis to calculate the ICI and combined ICI and TBM to discern disease prognosis.

According to the results, patients with high ICI scores demonstrated better outcomes than those with low ICI scores. Patients with a high combined TMB and ICI score experienced the best outcomes. Combining these 2 scoring modalities produces an accurate picture of survival in bladder cancer, the researchers concluded.

Reference: Zhang Y, Wang Y, Wang J, Zhang K. The immune cell infiltration patterns and characterization score in bladder cancer to identify prognosis. Front Genet. 2022;13:852708. doi:10.3389/fgene.2022.852708