Clinical data used in drug-coated balloons (DCBs) and drug-eluting stents (DESs) in peripheral artery disease (PAD) are high quality in general, according to a study published in International Journal of Technology Assessment in Health Care.

In this systematic review of four electronic databases, researchers identified over 1,700 publications, and included six articles for analysis (four cost-effective analyses and two cost-utility analyses). They noted that the methodological and reporting quality of the studies was assessed using three different tools, the Drummond, Cooper, and CHEERS (Consolidated Health Economic Evaluation Reporting Standards) checklists.

The researchers observed that the studies used good-quality data sources. The level of evidence used for clinical effect sizes, safety data, baseline clinical data, and costs was of high quality in general, they noted.  However, an evaluation of the reporting quality suggested that essential information was lacking.

While the clinical data used are from generally robust studies, the researchers concluded that “the quality of reporting represents a concern when interpreting the results provided by these economic studies.”



Keywords: Drug-coated balloon, Drug-eluting stent, Economic evaluation, medical device, Peripheral artery disease, Systematic review