A biomaterial-associated infection has proven to be a serious complication for orthopedic surgeons, and current infection prevention looks to anti-infective biomaterials. Researchers examined Dadapin-1, a peptide, and how its expression by assaying its MIC, MBIC, and MBC on clinical strains of relevant bacterial species could lead to the potential for safer biomaterial. The researchers determined that this peptide was non-cytotoxic, and because it exhibited significant antibacterial properties, it could be considered for future surgical applications.
Reference: Campoccia D, Montanaro L, Ravaioli S, et al. Antibacterial Activity on Orthopedic Clinical Isolates and Cytotoxicity of the Antimicrobial Peptide Dadapin-1. Int J Mol Sci. 2023 Jan 2;24(1):779. doi: 10.3390/ijms24010779. PMID: 36614222; PMCID: PMC9821071.
READ MORE
