A combination of chronic kidney disease (CKD) and multimorbidity increases the risk of cardiovascular and renal complications in patients with type 2 diabetes, according to a study published in Nephron.

In this population-based cohort study, researchers estimated the rates of cardiovascular and renal outcomes among patients with type 2 diabetes and CKD by assessing a sample of 106,369 patients between 2008 and 2017. Analyses were stratified by prevalent heart failure (HF), anemia, and resistant hypertension.

According to the results, the rate of all-cause hospitalization was 189 (95% confidence interval [CI], 187-191) per 1,000 person-years with cardiovascular-related hospitalizations being more frequent than kidney-related outcomes. The results showed the rate of acute kidney failure was 77.3 (95% CI, 76.2-78.5) per 1,000 person-years. Patients with HF experienced a four times higher rate for cardiovascular events compared with those without. Rates of hospitalization increased from five- to sixfold with increasing Kidney Disease Improving Global Outcomes severity, the researchers noted.

“Multimorbidity and advance stages of CKD increase the risk of cardiovascular and renal complications among patients with type 2 diabetes. Earlier CKD diagnosis as well as interventions and coordinated care addressing other comorbid conditions present at diagnosis may reduce the overall disease burden in this population,” the researchers concluded.

Keywords:  Chronic kidney disease, Clinical outcomes, Real-world data, Type-2 diabetes

Link: https://pubmed.ncbi.nlm.nih.gov/33789294/