Chronic obstructive pulmonary disease (COPD) is frequently a comorbidity in patients with heart failure (HF). A study assessed the influence of COPD on circulating levels and prognostic value of HF biomarkers. The results appeared in the Journal of Cardiovascular Medicine.

Researchers analyzed data from 8,088 patients with chronic HF, known COPD status, NT-proBNP and hs-TnT values (n = 8,088), and a subgroup (n = 3,414) with sST2 values.

The results showed that patients with COPD (n = 1,249, 15%) had higher NT-proBNP and hs-TnT, but not sST2 (P = 0.165). Over a median 2 years of follow-up, 21% of patients died, and 16% died from cardiovascular causes, 28% were hospitalized for HF over 1.8 years (0.9-2.1). NT-proBNP, hs-TnT and sST2 predicted the three end points regardless of COPD status, the researchers noted. They further noted that patients with all three biomarkers higher than or equal to end-point and COPD-status-specific cut-offs were also those with the worst prognosis.

Among patients with HF, those with COPD have higher NT-proBNP and hs-TnT, but not sST2. All these biomarkers yield prognostic significance regardless of the COPD status,” the researchers concluded.

Keywords: NT-proBNP, COPD, hs-TnT