This case report presents the first documented instance of treating stress-induced alopecia areata (AA) using a combination of 5% Minoxidil and targeted stress reduction strategies. The subject, a 28-year-old woman with no prior medical or family history of autoimmune disorders, developed AA shortly after experiencing prolonged emotional stress. Following diagnosis, she was treated with topical Minoxidil alongside mindfulness meditation, emotional support, and community engagement. The patient experienced notable hair regrowth and psychological improvement within three months. However, a recurrence occurred after she discontinued stress management and faced a new personal crisis, further reinforcing the role of stress in triggering AA. Reintroduction of the same treatment plan again led to recovery, suggesting a synergistic effect between pharmacologic and psychosocial therapies.
The report highlights the pathophysiological role of stress in AA, involving both autoimmune and neurogenic mechanisms, including HPA axis activation and inflammatory mediators. While Minoxidil effectively supports follicular regeneration, it does not address the root psychological triggers, making stress management essential for sustained remission. Psychosocial interventions such as mindfulness and CBT are increasingly recognized as vital components in managing stress-related AA. The case underscores the need for a holistic approach that combines medical and psychological care to improve long-term outcomes.
Reference: Alotiby AA. Integrating Psychological Support and Topical Therapy for the Effective Management of Stress-Induced Alopecia Areata: A Case Report. Cureus. 2025 Jan 12;17(1):e77317. doi: 10.7759/cureus.77317. PMID: 39935934; PMCID: PMC11812484.
