Investigators of a recent study included a population of 15,104 women, with a median age of breast cancer diagnosis of age 62, to determine if they carried an increased risk for contralateral breast cancer (CBC). The women included in the study had the germline pathogenic variants (PVs) in ATM, BRCA1, BRCA2, CHEK2, and PALB2.  It was determined that women who carried these germline PVs were at a greater risk of developing CBC. Investigators of the study aimed to improve the ability to understand the risk of CBC based on a patient’s predisposition with PV genes in order to improve surveillance and disease management strategies for breast cancer survivors.



Yadav S, Boddicker NJ, Na J, et al. Contralateral Breast Cancer Risk Among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2. J Clin Oncol. 2023;JCO2201239. doi:10.1200/JCO.22.01239