In a cross-sectional observational study, blood coagulability and breathing-related parameters during sleep were assessed in patients with obstructive sleep apnea (OSA). In 903 patients who were diagnosed by standard polysomnography, researchers used Pearson’s correlation, binary logistic regression, and restricted cubic spline evaluation to study the association between coagulation markers and OSA. It was found that with heightened severity in OSA, there was a considerable decrease in platelet distribution width and activated partial thromboplastin time. There was a positive association between platelet distribution width and apnea-hypopnea index, oxygen desaturation index, and microarousal index, while a negative association was seen between platelet distribution width and sleep time percentage with oxygen saturation under 90%. Activated partial thromboplastin time had a negative correlation with apnea-hypopnea index and oxygen desaturation index. Apnea-hypopnea index and oxygen desaturation index heightened the risk of irregular platelet distribution width, also increasing cardiovascular risk.
Reference: Yang J, Xue W, Wei Z, et al. The Associations of Platelet Activation and Coagulation Parameters with Obstructive Sleep Apnoea: A Large-Scale Observational Study. Int J Clin Pract. 2023;2023:5817644. doi:10.1155/2023/5817644
