A study published in the European Journal of Clinical Nutrition shows that arterial stiffness (AS), one of the complications of type 2 diabetes, is associated with low 25-hydroxyvitamin D(25(OH)D).
In this study, researchers analyzed just over 600 patients with type 2 diabetes who were divided into two groups: AS group (baPWV ≥15,500 cm/s) and the control group (baPWV <1,550 cm/s).
The results showed that Heart rate (HR) and systolic pressure (SBP) were higher while body weight and body mass index (BMI) were less in AS group compared with the control group (all P<0.05). Also, patients with AS showed lower 25(OH)D and higher rate of 25(OH)D deficiency (42 ± 16 vs. 45 ± 17 mol/L; 68% vs. 64%; all P<0.05) juxtaposed to their counterparts without AS. BaPWV was negatively associated with 25(OH)D (P=0.004), while positively associated with age, duration of diabetes, HR, SBP, and low-density lipoprotein cholesterol and negatively associated with body weight and BMI (all P<0.05), the researchers noted. Moreover, linear regression revealed that 25(OH)D was the negatively associated with baPWV (P=0.01).
“Patients [with type 2 diabetes] with AS had lower 25(OH)D and higher-rate of 25(OH)D deficiency. There was a negative relationship between 25(OH)D and AS assessed by baPWV,” the researchers concluded.
Keywords: type 2 diabetes mellitus, systolic pressure, 25-hydroxyvitamin D