Patients with co-existing coronary artery disease (CAD) and peripheral artery disease (PAD) may benefit from electrocardiography (ECG) monitoring during treadmill testing, which may identify major adverse cardiac events (MACE), according to a study published in the Journal of Vascular Surgery.

Researchers assessed the risk of MACE, major adverse limb events (MALE), and all-cause mortality in 4,128 patients with myocardial ischemia on ECG compared to 340 patients without ischemia.

Following analysis, the results showed that ECG group had a higher percentage of diabetes mellitus, carotid artery disease, exercise-induced angina, and dyspnea. Post-exercise ABI was lower in the positive ECG group, while resting ABI was similar in both groups. After an average follow-up of eight years, MACE were significantly greater in the positive ECG group, while MALE were notably less frequent.

“ECG monitoring during vascular treadmill testing identified a subset of patients with more frequent MACE but less MALE,” the researchers concluded.


Keywords: Peripheral artery disease, coronary artery disease, major adverse cardiac event, major adverse limb event, polyvascular disease