High-Risk Patients with COVID-19: Outpatient Management to Prevent Progression - POCN

High-Risk Patients with COVID-19: Outpatient Management to Prevent Progression

Infectious diseases | August 24, 2021


1.0 CME Credit
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Launch Date:

August 24, 2021

Expiration Date:

August 24, 2022

primary audience:

Primary care clinicians

Relevant Terms:

No Data Found

course information

Patients with COVID-19 have varied risk for increasing severity of disease, with the chance of progression and mortality being higher in older patients and those with comorbidities. Monoclonal antibody therapies that prevent the need for hospitalization in high-risk outpatients who have COVID-19 have been given Emergency Use Authorization by the FDA. These agents include a cocktail consisting of casirivimab and imdevimab and a cocktail of bamlanivimab and etesevimab.

This activity High-Risk Patients with COVID-19: Outpatient Management to Prevent Progression will provide clinicians who manage outpatients with COVID-19 with a review of the most current management guidelines and information on the mechanism of action, efficacy and safety data, and patient eligibility for the monoclonal antibodies that have received emergency use authorization (EUA) by the FDA to treat outpatients with COVID-19.

Welcome and Introduction
Recommendations for Outpatient Management of COVID-19
Efficacy and Safety of Monoclonal Antibodies for the Outpatient Management of COVID-19
Q&A Session and Activity Roundup


Peter Chen, MD
Professor of Medicine and Biomedical Sciences Director,
Division of Pulmonary and Critical Care Medicine
Cedars-Sinai Medical Center
Los Angeles, CA

Peter Chen, MD obtained a BS in Electrical Engineering from the University of Texas, his MD from Baylor College of Medicine, and then trained in Internal Medicine at UT Southwestern. Subsequently, he did his fellowship in Pulmonary and Critical Care Medicine at the University of Washington where he also started basic research training in lung biology. He started his academic career as an Assistant Professor at the University of Washington and rose to the rank of Associate Professor before being recruited to Cedars-Sinai in 2013 to become the Director of the Division of Pulmonary and Critical Care Medicine and where he is currently a Professor of Medicine and Biomedical Sciences.

During his time at Cedars-Sinai, he has transformed the Division by expanding the clinical care programs and mirroring it with a world-class research program. Accordingly, the Division has had a quick rise in the US News and World Report rankings to #3 in 2020. Furthermore, the Women’s Guild Lung Institute has developed into a premier pulmonary research institute housing internationally recognized researchers that conduct basic, translational, and clinical research in interstitial lung disease, pulmonary vascular disease, acute lung injury, COVID-19, cystic fibrosis, and regeneration.

Dr. Chen has been highly accomplished as a physician-scientist that has been continually NIH-funded since fellowship. He has published in some of the top clinical and basic science journals including the New England Journal of Medicine, JAMA, American Journal of Respiratory and Critical Care Medicine, JCI Insight, Cell Reports, among many others. He was awarded the Jo Rae Wright Award for Outstanding Science by the American Thoracic Society (ATS) in 2013, which is a highly competitive award presented to a rising star within this international respiratory society of 16,000+ members. He has served on study sections for the NIH, VA merit and American Heart Association, is on the editorial board of the American Journal of Respiratory Cellular and Molecular Biology, held several leadership positions in the ATS, and was part of the California COVID-19 Academic Advisory Board.

Raymund R. Razonable, MD
Professor of Medicine Mayo Clinic
Rochester, MN

Raymund R. Razonable, MD is Professor of Medicine and Distinguished Clinician at the Mayo Clinic College of Medicine and Science in Rochester, Minnesota. He serves as the Vice Chair of the Division of Infectious Diseases, and Program Director of the Infectious Diseases Fellowship Training Programs at the Mayo Clinic.

Dr. Razonable’s clinical, educational and research interests include infections related to organ transplants, with specific focus on cytomegalovirus infections. He has authored more than 230 peer-reviewed original and review articles, more than 30 book chapters, and almost 200 abstracts on these topics. He is a sought-after speaker at national and international meetings. Dr. Razonable is editor of Transplant Infectious Diseases and serves on the editorial boards of infectious diseases and transplantation journals.

A recipient of numerous awards and honors throughout his career, Dr. Razonable was inducted as a Fellow of the Infectious Diseases Society of America, and Fellow of the American Society of Transplantation.

During the past year, Dr. Razonable focused his work on the COVID-19 pandemic. He led the Mayo Clinic trials on IL-6 inhibition trials and spike monoclonal antibodies. He is the Program lead of the enterprise-wide Monoclonal Antibody Program at Mayo Clinic.

The intended audience for this educational initiative is primary care clinicians who are responsible for the outpatient management of patients with mild-to-moderate COVID-19.

At the conclusion of this education, participants should be able to:

  • Integrate the most recent recommendations when developing management strategies for outpatients with COVID-19
  • Assess the mechanism of action and efficacy and safety data for monoclonal antibodies that have FDA Emergency Use Authorization for managing outpatient COVID-19

This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Potomac Center for Medical Education and Rockpointe. The Potomac Center for Medical Education is accredited by the ACCME to provide continuing medical education for physicians.

The Potomac Center for Medical Education designates this live activity for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For questions regarding CME credit or the evaluation, please email contact@potomacme.org.

The Potomac Center for Medical Education (PCME) adheres to the policies and guidelines, including the Standards for Commercial Support, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other professional organizations, as applicable, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous.

All persons in a position to control the content of a continuing medical education program provided by PCME are required to disclose any relevant financial relationships with any commercial interest to PCME as well as to learners. All conflicts of interest are identified and resolved by PCME in accordance with the Standards for Commercial Support in advance of delivery of the activity to learners.

Program Faculty and Steering Committee
The faculty, authors and content developers reported the following relevant financial relationships that they or their spouse/partner have with commercial interests:
Peter Chen, MD: Consultant/Independent Contractor: Eli Lilly, Gilead

Raymund Razonable, MD: Grant/Research Support: Gilead, Regeneron, Roche

Planners and Managers
The planners and mangers reported the following relevant financial relationships that they or their spouse/partner have with commercial interests:
Terry A. Glauser, MD, MPH: Nothing to disclose

Content Reviewers
The content reviewers reported the following relevant financial relationships that they or their spouse/partner have with commercial interests:
Katie Propst, PhD: Nothing to disclose

The contents of some CME/CE activities may contain discussions of non-approved or off-label uses of some agents mentioned. Please consult the prescribing information for full disclosure of approved uses.

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There is no fee for this activity. To receive credit, participants must take the pre-test, view this CME activity in its entirety, and then complete the post-test, with a score of 75% or better, and evaluation. The estimated time for completion of this activity is 1 hour. To receive their certificates, participants must demonstrate mastery of the presented material via the post-test. Participant is allowed to take the post-test multiple times.

Jointly provided by the Potomac Center for Medical Education and Rockpointe

Education resources provided in collaboration with


This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc.

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