Nonmelanoma Skin Cancers: Current and Emerging Checkpoint Inhibitors for Treating Advanced Basal Cell and Squamous Cell Carcinomas - POCN

Nonmelanoma Skin Cancers: Current and Emerging Checkpoint Inhibitors for Treating Advanced Basal Cell and Squamous Cell Carcinomas

Oncology | August 18, 2021

Credits:

1.0 CME Credit, 1.0 ANCC contact hour, ABIM MOC and MIPS-eligible
Start Course

Launch Date:

August 18, 2021

Expiration Date:

August 18, 2022

primary audience:

Clinicians who are responsible for the diagnosis and management of patients with advanced NMSC (Non-Melanoma Skin Cancer), Oncologists, Oncology nurses

Relevant Terms:

Basal Cell Carcinoma, Cutaneous Squamous Cell Carcinoma, Immunotherapy

course information

PROGRAM DESCRIPTION
The incidence of nonmelanoma skin cancers (NMSC), including cutaneous squamous cell carcinomas (CSCC) and basal cell carcinomas (BCC), is increasing globally. Although these cancers are treatable with surgery or radiotherapy, locally advanced or metastatic forms of these carcinomas are life-threatening, difficult to treat, are not amenable to those standard options, and historically, have had few treatment options. Greater knowledge of the role of the immune system in the development of cancer, and of the role of programmed death-1 (PD-1) in evading immune clearance, has led to the study of PD-1 and PD-L1 inhibitors in the management of advanced and metastatic NMSCs. This research has led to the approval of a checkpoint inhibitor as the first treatment specifically for advanced CSCC and the continued development of checkpoint inhibitors for treating advanced BCC. Oncologists need to be aware of what constitutes a thorough diagnostic evaluation and accurate staging of patients to develop more effective individualized, evidence-based management plans. In addition, oncologists need to understand current evidence regarding the use of immunotherapies such as checkpoint inhibitors.

The CME program, Nonmelanoma Skin Cancers: Current and Emerging Checkpoint Inhibitors for Treating Advanced Basal Cell and Squamous Cell Carcinomas, will provide oncologists with current guideline-based diagnostic, staging, and treatment strategies for patients with advanced BCC and CSCC as well as how newly approved and agents in development fit into treatment strategies.

AGENDA
Welcome and Introductions
Evidence-based Diagnosis and Staging of Advanced Nonmelanoma Skin Cancers
Current and Emerging Therapies for Treating Advanced BCC and CSCC
Q&A Session and Activity Roundup

PROGRAM FACULTY AND STEERING COMMITTEE

Roman Groisberg, MD
Assistant Professor,
Medical Oncology Department of Melanoma and Sarcoma
Rutgers Cancer Institute of New Jersey
New Brunswick, NJ

Roman Groisberg, MD is excited to join Rutgers Cancer Institute of New Jersey following an internal medicine residency at Yale-New Haven hospital and a hematology/oncology fellowship at MD Anderson Cancer Center. He sees patients as part of the Melanoma and Sarcoma Program and the Phase I/Investigational Therapeutics Program at Rutgers Cancer Institute.

Dr. Groisberg has always believed that life is about human connections – reaching out to another person for advice, reassurance, a hug, or a conversation. It is such moments that have guided and defined his life through a series of mentors, each impressing upon him important values and life lessons. Mentors steered him toward research in biology, medical school, oncology, and clinical trials. Finally, synthesizing his molecular biology background with his interest in early phase clinical trials into a career developing targeted cancer therapies.

Every cancer and every patient is unique and there is no “usual” treatment. Treatment decisions are made using the latest in diagnostic techniques such as next-generation DNA sequencing which gives the particular genomic profile of a tumor. Dr. Groisberg uses this data in his practice to design an individualized treatment plan for each of his patients implementing a variety of tools at his disposal including targeted therapy, chemotherapy, and immunotherapy to achieve the best possible results. He also ensures that the treatment plan fits with the patient’s lifestyle.

It is Dr. Groisberg’s goal to provide the latest and most advanced therapies for his patients, making sure that novel drugs are available as part of a clinical trial. He educates his patients on the importance of clinical trials and encourages them to participate not only for themselves, but for cancer patients worldwide – today and in the future. His particular interest is in drugs that target specific drivers of a tumor.

Dr. Groisberg is the author or co-author of numerous publications, reviews, book chapters, abstracts, and presentations related to targeted therapy in cancer, especially related to sarcomas. He has received the prestigious Connie and Jim Walter endowed fellowship for sarcoma research as well as the Daniel Benedict Gazan endowed sarcoma fellowship. He has also received the American Society of Clinical Oncology merit award for outstanding research in targeted sarcoma therapy as well as a top prize by the Texas State Oncology Society research competition. He is a member of several national and international cancer societies including ASCO, EACR, AACR, and CTOS, where he presents his research.

Max Lenowitz, CRNP
Jefferson Medical Oncology
Philadelphia, PA

Max Lenowitz, CRNP has been an oncology nurse for three years specializing in cutaneous malignancies. He has worked at Jefferson Medical Oncology for the duration of his career and has a passion for patient care, education, and helping patients navigate through their oncologic journeys. Max completed his Masters in Nursing as a Family Nurse Practitioner in 2020 and hopes to continue his career in cutaneous malignancies as a nurse practitioner.

Melissa Wilson, MD, PhD
Oncology Fellowship Program Director/Melanoma Program Director
St. Luke’s Cancer Center – St. Luke’s University Health Network
Easton, PA

Melissa Wilson, MD, PhD received her PhD in Biochemistry and Molecular Biology from Georgetown University; an MD from Thomas Jefferson University; and completed her Internal Medicine residency and Hematology and Medical Oncology fellowship at the University of Pennsylvania, where she focused on melanoma genetics. She began her independent melanoma clinical practice at NYU’s Langone’s Perlmutter Cancer Center, and joined Thomas Jefferson University’s Sidney Kimmel Cancer Center in 2018 , and now is at St. Luke’s Cancer Center, St. Luke’s University Health Network as the Medical Oncology Fellowship Director and the Director of the Melanoma Program. In addition to treating melanoma patients, Dr. Wilson leads clinical and translational research projects focused on improving treatment options for patients with melanoma. She is particularly interested in novel targeted therapies for melanoma patients who do not respond to currently available treatment options. Dr. Wilson has received numerous awards/grants to fund melanoma trials.

TARGET AUDIENCE
The intended audience for this educational initiative is oncologists, oncology nurses, and other clinicians who are responsible for the diagnosis and management of patients with advanced NMSC (Non-Melanoma Skin Cancer).

EDUCATIONAL OBJECTIVES
At the conclusion of this activity, participants should be able to:

  • Make timely diagnoses of patients with BCC or CSCC using current evidence-based criteria
  • Accurately stage and risk stratify patients with BCC or CSCC to establish optimal follow-up regimens
  • Make evidence-based treatment selections for patients with advanced BCC or CSCC
  • Assess the safety and efficacy of emerging therapies for advanced BCC or CSCC

PHYSICIAN ACCREDITATION STATEMENT
This activity has been planned and implemented in accordance with the accreditation requirements and policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint providership of the Potomac Center for Medical Education and Rockpointe. The Potomac Center for Medical Education is accredited by the ACCME to provide continuing medical education for physicians.

PHYSICIAN DESIGNATION CREDIT STATEMENT
The Potomac Center for Medical Education designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

For questions regarding CME/MOC/MIPS credit or the evaluation, please email contact@potomacme.org.

ABIM MOC DESIGNATION STATEMENT

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.0 Medical Knowledge MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

To recieve CME credit and/or MOC points, you MUST pass the post-test and complete the evaluation. For ABIM MOC points, your information will be shared with the ABIM through PCME’s ACCME Program and Activity Reporting System (PARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.

MOC APPROVAL STATEMENT

Through the American Board of Medical Specialties (“ABMS”) ongoing commitment to increase access to practice relevant Continuing Certification Activities through the ABMS Continuing Certification Directory, “Nonmelanoma Skin Cancers: Current and Emerging Checkpoint Inhibitors for Treating Advanced Basal Cell and Squamous Cell Carcinomas” has met the requirements as a MOC Part II CME Activity (apply toward general CME requirement) for the following ABMS Member Boards:

MOC Part II CME Activity
Family Medicine

NURSING ACCREDITATION AND DESIGNATION STATEMENT

In support of improving patient care, this activity has been planned and implemented by Amedco LLC and Rockpointe Corporation. Amedco LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

NURSES (ANCC)
Amedco LLC designates this activity for a maximum of 1 ANCC contact hour.

Click here to download nursing learner notification.

MIPS CREDIT DESIGNATION

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS).

In order to fulfill requirements for MIPS improvement activity, participants will need to fill out 2 brief follow-up surveys at 30- and 90-days post-activity.

DISCLOSURE INFORMATION
Potomac Center for Medical Education (PCME) adheres to the policies and guidelines, including the Standards for Integrity and Independence in Accredited CE, set forth to providers by the Accreditation Council for Continuing Medical Education (ACCME) and all other relevant professional organizations, stating those activities where continuing education credits are awarded must be balanced, independent, objective, and scientifically rigorous.

All persons in a position to control the content of an accredited continuing education program provided by the Potomac Center for Medical Education are required to disclose to PCME all financial relationships with any ineligible company within the past 24 months. All financial relationships reported are identified as relevant and mitigated by PCME in accordance with the Standards for Integrity and Independence in Accredited CE in advance of delivery of the activity to learners. The content of this activity was vetted by PCME to assure objectivity and that the activity is free of commercial bias. All relevant financial relationships have been mitigated by PCME.

Program Faculty and Steering Committee
The faculty, authors and content developers reported the following relevant financial relationships with ineligible companies:

Roman Groisberg, MD: Consultant/Independent Contractor: GLG; Grant/Research Support: Bristol Myers Squibb, Merck, Philogen, Regeneron, Roche/Genentech; Speaker’s Bureau: Deciphera

Max Lenowitz, CRNP: Nothing to disclose

Melissa Wilson, MD, PhD: Honoraria: Eisai

Planners and Managers
The planners and mangers reported the following relevant financial relationships with ineligible companies:

Chad Williamson, MS, MBA, CMPP: Nothing to disclose

Content Reviewers
The content reviewers reported the following relevant financial relationships with ineligible companies:

Katie Propst, PhD: Nothing to disclose

FDA DISCLOSURE
The contents of some CME activities may contain discussions of non-approved or off-label uses of some agents mentioned. Please consult the prescribing information for full disclosure of approved uses.

HARDWARE/SOFTWARE REQUIREMENTS
Please ensure the computer system you plan to use meets the following minimum requirements:

  • Operating System: Windows 98 or higher & Macintosh 2.2 or higher
  • Internet Browser (Mac & Windows): Google Chrome, Safari 5.0.6 or higher, Firefox 3.0.3 or higher, & Opera 5 or higher
  • Broadband Internet connection: Cable, High-speed DSL & any other medium that is internet accessible
  • Media Viewing Requirements: Adobe Reader, Microsoft PowerPoint, Flash Player & HTML5

INSTRUCTIONS FOR PARTICIPANTS AND OBTAINING CME/ANCC/MIPS CREDIT AND MOC POINTS
There is no fee for this activity. To receive credit, participants must take the pre-test, view this CME/MOC/ANCC/MIPS activity in its entirety, and then complete the post-test, with a score of 70% or better, and evaluation. The estimated time for completion of this activity is 1 hour. To receive their certificates, participants must demonstrate mastery of the presented material via the post-test. Participant is allowed to take the post-test multiple times.

Jointly provided by the Potomac Center for Medical Education and Rockpointe


Nursing Credit provided by Amedco.

This activity is supported by an independent medical education grant from Regeneron Pharmaceuticals, Inc and Sanofi Genzyme.

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