Researchers conducted a meta-analysis to investigate whether there is a relationship between inflammatory bowel disease (IBD; including ulcerative colitis and Crohn’s disease) and risk of Parkinson’s disease. This study was published in Neural Regeneration Research.

The investigators queried PubMed, Embase, and Cochrane databases to identify observational studies published through October 2019. Nine studies were included in the analysis, comprising 12,177,520 patients.

The overall risk of Parkinson’s disease was significantly higher among patients with IBD compared with the general population (adjusted risk ratio [RR]=1.24, 95% confidence interval [CI] 1.15-1.34, P< 0.001). Additionally, the incidence of IBD was significantly increased before and after Parkinson’s disease diagnosis (adjusted hazard ratio [HR]=1.26 and 1.40, respectively, both P<0.001). The adjusted, pooled risk of Parkinson’s disease was significantly greater in patients with ulcerative colitis (HR=1.25, 95% CI 1.13-1.38, P<0.001) or Crohn’s disease (1.33, 95% CI 1.21-1.45, P<0.01) specifically.

For patients with IBD, there were no differences in Parkinson’s disease risk according to sex; however, patients >65 years old had an elevated risk compared to younger patients (HR = 1.32 and 1.24, respectively). Untreated IBD was associated with a significantly increased Parkinson’s disease risk compared with patients who received treatment (HR = 1.6).

Via: Neural Regeneration Research;year=2022;volume=17;issue=2;spage=344;epage=353;aulast=Zhu