Studies suggest that the risk of migraine is contributed by both genetic and environmental factors. A study published in Neurological Sciences sought to assess the association between the risk of migraine and genetic polymorphisms in the ANKDD1B gene in a large Chinese patient sample.

The study comprised 882 patients with migraine and 1,784 age-matched controls. Subsequently, a list of 12 tag single nucleotide polymorphisms (SNPs) located within the ANKDD1B gene region were genotyped. Distributions of SNP genotypes and alleles between patients and controls were examined to investigate the associations between the risk of migraine and genetic polymorphisms.

The researchers used a database to discern the impact of the significant SNPs on gene expressions. They observed that stop-gain SNP, rs34358, was notably correlated with the risk of migraine (P=5.66 × 10-7). The A allele of this SNP was significantly associated with a decreased risk of migraine (odds ratio [OR]=0.73; 95% confidence interval [CI] 0.65-0.83).

Moreover, a dose-dependent pattern was identified in the genotypic analyses. The OR for genotype AA versus GG was 0.55 (95% CI 0.42-0.72), while for AG versus GG it was 0.74 (95% CI 0.62-0.88). The researchers noted that further bioinformatics analysis showed multiple significant signals for the association between SNP rs34358 and gene expression levels of ANKDD1B.

The researchers concluded that “we have provided population-based evidence for the association between genetic polymorphisms of the ANKDD1B gene and the risk of migraine. A protein-truncating variant was significantly associated with a decreased risk of migraine in the samples recruited from the Chinese Han population.”



Keywords: ANKDD1B, Case–control study, Migraine, Polymorphisms