Using a two-sample bidirectional Mendelian randomization (MR) evaluation, researchers looked at the relationship between psoriasis, psoriatic arthritis (PsA), and inflammatory bowel disease (IBD). It was found that PsA and psoriasis heightened odds of the development of Crohn’s disease. A positive association was seen with psoriasis and PsA with genetically predicted Crohn’s disease at 42.5% and 44.8% risks, respectively. On the other hand, the approximations of the MR gave a small amount of support to the causal impact of psoriasis and PsA on ulcerative colitis. Overall, the researchers found that their MR evaluation strengthened the evidence of the bidirectional impact of psoriasis, which includes PsA, and Crohn’s disease.
Reference: Sun Y, Li Y, Zhang J. The causal relationship between psoriasis, psoriatic arthritis, and inflammatory bowel diseases. Sci Rep. 2022;12(1):20526. doi:10.1038/s41598-022-24872-5
