Time-adjusted Mayo endoscopic score (TA-MES), a novel scoring scale, effectively indicated cumulative inflammatory burden and predicted disease extension in patients with ulcerative colitis (UC), according to a recent study published in Gastroenterology Report.
Researchers reviewed 1,487.02 patient-years of data from 295 patients with proctitis or left-sided colitis who underwent colonoscopies in a registry database using their TA-MES formula—cumulative average MES during a surveillance period divided by the length of the endoscopic examination interval.
Reportedly, TA-MES was significantly associated with disease extension in proctitis (hazard ratio [HR], 2.90; 95% CI, 1.58-5.33; P=.001) and left-sided colitis (HR, 1.89; 95% CI, 1.16-3.09; P=.011).
Investigators observed disease extension in 140 patients (47.5%) and identified hemoglobin levels of <90 g/L and appendiceal skip inflammation as related risk factors. Conversely, age, left-sided colitis at diagnoses, former smoking, and 5-aminosalicylic acid dose were identified as protective factors. MES at diagnosis, maximal MES, and mean MES were not viable predictors for disease.
The authors recommended further research into the potential of TA-MES in other diseases similar to UC.
Reference: Wan J, Wang X, Zhang Y, Xue X, Jia H, Wang M, et al. Time-adjusted average Mayo endoscopic score predicts the risk of disease extent progression in distal ulcerative colitis patients. Gastroenterol Rep (Oxf). 2022;10:goac019. doi:10.1093/gastro/goac019