Researchers measured adherence and persistence rates and examined the utilization and switching patterns of phosphate binders (PBs) in patients with dialysis-dependent chronic kidney disease (DD-CKD). The patients were divided into cohorts based on the primary PB they used. The results showed that adherence rates ranged from 63.8% for lanthanum carbonate to 67.7% for sevelamer, while persistence rates varied from 85.1% for calcium acetate to 89.5% for ferric citrate. Overall, 20.5% of patients experienced one switch, and 2.3% had two or more switches. The study found positive net switching rates for ferric citrate, sucroferric oxyhydroxide, and lanthanum carbonate (ranging from 2% to 10%), indicating that more patients switched to these PBs than switched away from them. Researchers concluded that adherence and persistence rates were generally low, with slight variations across different PBs.
Reference: Berner T, Ferro C, Dieguez G, et al. Real-World Phosphate Binder Use Among Dialysis-Dependent Patients With CKD. Nephron. 2023 Mar 30. doi: 10.1159/000530230. Epub ahead of print. PMID: 36996774.
READ MORE > https://pubmed.ncbi.nlm.nih.gov/36996774/
