Researchers of a recent study investigated the potential causal relationship between specific gut microbiota and chronic kidney disease (CKD). The researchers performed Mendelian randomization (MR) analysis using four different methods to assess the causal relationship between 211 gut microbiotas and six CKD-related outcomes. The results showed that 36 intestinal microflora were associated with various outcomes of CKD. Notably, Class Bacteroidia exhibited a strong causal relationship with lower estimated glomerular filtration rate (eGFR), which is an indicator of kidney function. Further research in this area may contribute to the development of new interventions to prevent and delay the progression of CKD by targeting the gut microbiota.
Reference: Li N, Wang Y, Wei P, Min Y, et al. Causal Effects of Specific Gut Microbiota on Chronic Kidney Diseases and Renal Function-A Two-Sample Mendelian Randomization Study. Nutrients. 2023 Jan 11;15(2):360. doi: 10.3390/nu15020360. PMID: 36678231; PMCID: PMC9863044.
READ MORE > https://pubmed.ncbi.nlm.nih.gov/36678231/
