This systematic review and meta-analysis explores the impact of systemic lupus erythematosus (SLE) on male reproductive health. While much research has focused on reproductive challenges in female patients with SLE, male patients also face significant risks, including sexual dysfunction, hormonal imbalances, and impaired semen quality. The study identified a higher incidence of erectile dysfunction (ED) in male patients with SLE and found elevated levels of reproductive hormones such as follicle-stimulating hormone (FSH) and luteinizing hormone (LH). Sperm count was also significantly lower in SLE patients compared to controls. The findings highlight the need for increased clinical awareness and targeted interventions to address reproductive health in male patients with SLE, emphasizing the importance of including reproductive counseling in their management.
The meta-analysis, which reviewed 5002 articles and included nine qualifying studies, revealed that male patients with SLE are more likely to experience issues related to sexual function, hormonal disturbances, and sperm quality. These challenges can affect fertility and overall reproductive outcomes. The study calls for greater attention to male reproductive health in SLE management, noting that many patients may not be aware of these risks. The findings suggest that routine discussions about sexual health and reproductive counseling should be integrated into clinical care for male patients with SLE to improve their overall well-being.
Reference: Zhu J, Zhu Q, Li X, et al. Systemic lupus erythematosus and male reproductive health: A systematic review and meta-analysis. Autoimmun Rev. 2025 Mar 26;24(4):103742. doi: 10.1016/j.autrev.2025.103742. Epub 2025 Jan 7. PMID: 39788440.
