A study presented at the European Congress of Rheumatology revealed that patients with psoriatic arthritis have higher levels of vascular inflammation compared with healthy individuals. The study utilized positron emission tomography/computed tomography scan data from an ongoing phase 3 trial. The findings suggest that inflammation in psoriatic arthritis extends beyond the skin and joints and involves the cardiovascular system. The study did not find any association between disease activity and vascular inflammation.
Another study presented at the same congress highlighted that achieving remission with methotrexate or TNF inhibitors significantly reduces the risk of acute coronary syndrome in patients with psoriatic and rheumatoid arthritis, bringing the risk levels closer to those of healthy individuals. The current study analyzed data from the ongoing TOFA PREDICT trial, which aims to explore various aspects of psoriatic arthritis. The results showed that patients with psoriatic arthritis had greater vascular inflammation compared to the control group, even after adjusting for factors such as age, gender, body mass index, and mean arterial pressure. However, no associations were found between vascular inflammation and disease-related parameters in patients with psoriatic arthritis.
Reference: Campbell P. Psoriatic Arthritis Linked to Increased Vascular Inflammation, Regardless of Disease Activity. HCP Live. Updated May 31, 2023. Accessed May 31, 2023. https://www.hcplive.com/view/psoriatic-arthritis-linked-to-increased-vascular-inflammation-regardless-of-disease-activity
