Authors of a comprehensive review (2010-March 2024) of English, peer-reviewed studies in PubMed and Embase evaluated nonsurgical alternatives for alopecia, including stem cell–based approaches, low-level laser therapy, and natural oils. The authors synthesized clinical trials, systematic reviews, preclinical studies, and select case reports to examine mechanisms, safety, and clinical outcomes across device-based and biologic interventions.
Across studies, adipose-derived, hair-follicle, and induced pluripotent stem cell strategies were linked to improvements in hair density and shaft thickness, likely via paracrine signaling and angiogenesis. Low-level laser therapy may act through Wnt/β-catenin activation and enhanced scalp perfusion. Oils such as rosemary and pumpkin seed may help through anti-inflammatory and hormonal pathways. Among options, adipose-derived stem cell–conditioned extract had the strongest support to date, while plant-derived extracellular vesicles and induced pluripotent stem cell approaches remain experimental. The authors conclude that more rigorously designed human trials are needed to validate efficacy, clarify mechanisms, and define use across scarring and non-scarring alopecias.
Reference: Smith T. Stem Cells, Laser Treatments, Other Alternative Therapies Effective for Alopecia. HCP Live. Published August 26, 2025. Accessed September 17, 2025. https://www.hcplive.com/view/stem-cells-laser-treatments-other-alternative-therapies-effective-alopecia
Link: https://www.hcplive.com/view/stem-cells-laser-treatments-other-alternative-therapies-effective-alopecia
