A study sought to assess the efficacy and tolerability of the ketogenic diet (KD) in preventing migraine in adolescents and adults. The results were published in Nutrition Reviews.
In this study, researchers used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses standard to review articles in PubMed, EMBASE, Scopus, Web of Science, LILACS, LIVIVO, Science Direct, and Cochrane Central Register of Controlled Trials databases. The Google Scholar, Directory of Open Access Journals, ProQuest, and OpenGrey databases were also included.
The population of interest, intervention, comparison, outcome, and study design strategy were all analyzed to discern the quality of the evidence. The risk of bias was assessed using the Joanna Briggs Institute critical appraisal tools. Overall, the analysis included 10 studies.
According to the results, most studies reported that KD reduced the number and severity of migraine attacks in patients, with minimal adverse effects reported. However, the researchers noted that the evidence on the effectiveness of the KD is low, so whether the final effect is due to the treatment remains inconclusive.
“This study represents an initial effort to systematize information on the efficacy and tolerability of KD and its variations in the prevention of migraine,” the researchers concluded.
Keywords: headache disorders, ketogenic diet, migraine, systematic review