Dr. John M. Mandrola discusses the CASTLE-HTx study with Dr. Christian Sohns and Dr. Philipp Sommer, and the focus of the conversation is on the treatment of patients with advanced heart failure and atrial fibrillation. The CASTLE-HTx study specifically examined the effectiveness of catheter ablation versus medical therapy in treating these patients. The endpoint of the study was a composite of death from any cause, left ventricular assist device implantation, or heart transplantation. This study indicates that catheter ablation may be a more effective treatment option than medical therapy alone for patients with advanced heart failure and atrial fibrillation, particularly in reducing cardiovascular death and all-cause mortality.
Reference: Mandrola J, Sohns C, Sommer P. Is AF Ablation the Fifth Pillar in Heart Failure Care? CASTLE-HTx. Medscape. Recorded August 28, 2023. Accessed September 19, 2023. https://www.medscape.com/viewarticle/995912
