A bioinformatics analysis published in Bioengineered evaluated the characteristics of immune cell infiltration and any associated diagnostic biomarkers in patients with ulcerative colitis.

The researchers screened 248 differentially expressed genes (DEGs) in patients with ulcerative colitis. The top 20 immune-related hub genes and pathways were included in the analysis. The team also identified four candidate diagnostic biomarkers (DPP10, S100P, AMPD1, and ASS1).

There were 13 differentially infiltrated immune cells in ulcerative colitis samples compared with control samples. Two infiltrated immune cells were only expressed in ulcerative colitis samples.

Among the biomarkers, DPP10 negatively correlated with neutrophils, S100P positively correlated with resting CD4 memory T cells, AMPD1 positively correlated with M2 macrophages, and ASS1 was inversely associated with neutrophils and positively correlated to CD8 T cells.

In conclusion, the authors wrote, “Taken together, these findings indicated that DPP10, S100P, AMPD1, and ASS1 may act as diagnostic biomarkers for ulcerative colitis, and that differential infiltrated immune cells may help to illustrate the progression of ulcerative colitis.”

Via: Bioengineered https://www.tandfonline.com/doi/full/10.1080/21655979.2020.1863016