Further VTX958 Trials Halted for Crohn’s Disease Despite Endoscopic Gains
Unsuccessful results were reported from a phase 2 trial of [...]
Gastroenterology
Further VTX958 Trials Halted for Crohn’s Disease Despite Endoscopic Gains
| Categories: gastroenterology
Unsuccessful results were reported from a phase 2 trial of the drug, VTX958, aimed at treating moderately to severely active Crohn’s disease. The trial did […]
Genetic Studies Link Inflammatory Bowel Disease to Increased Hemorrhoid Risk
Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn’s [...]
Study Reveals How Bowel Movement Frequency Impacts Gut Microbiome and Links to Chronic Diseases
A recent study analyzed the gut microbiome’s crucial role in [...]
Study Reveals Probiotic Bifidobacterium Bifidum BB1 Enhances Gut Barrier
Researchers have identified a unique probiotic strain, Bifidobacterium bifidum BB1, [...]
Study Highlights Persistent Microbial Dysbiosis in Pediatric Crohn’s Disease Despite Remission
Crohn’s disease is a complex inflammatory condition of the intestine [...]
Diet’s Role in Ulcerative Colitis: Results From Plant-Based Diet Study at Digestive Disease Week 2024
Research on diet's role in ulcerative colitis (UC) is limited, [...]
Breakthrough Stem Cell Therapy Shows Potential to Treat Hirschsprung Disease, Improving Gut Functionality
A study led by researchers at UCL and the University [...]
Mirikizumab Shows Promising Results in Phase 3 Crohn’s Disease Study
Eli Lilly and Company announced positive results from their phase [...]
Mesalamine: A New Ally Against Candida Infections
UC Davis Health researchers have discovered that mesalamine, a common [...]
Data Highlights Increased Chronic Kidney Disease Risk in Patients With Crohn’s Disease
Data presented at Digestive Disease Week 2024 indicates that patients [...]
Advancements in Inflammatory Bowel Disease Care: UNC Adopts Intestinal Ultrasound
The University of North Carolina (UNC) is on track to [...]
Mount Sinai Researchers Uncover Genetic Links Between Inflammatory Bowel Disease and Parkinson’s Disease
Researchers at the Icahn School of Medicine at Mount Sinai [...]
Study Reveals Diagnostic and Treatment Challenges of Microscopic Colitis
A study led by Dr. Walker Redd at the [...]
Diet Quality in Infancy Linked to Inflammatory Bowel Disease Risk
Researchers of a study examined whether early-life diet quality [...]
Study Finds Variability in IBD Endoscopic Scoring, Urges Standardization
Researchers of a study conducted a systematic review and meta-analysis [...]
Novel Strategy Inspired by Cancer’s Tactics Offers Hope for Ulcerative Colitis Treatment
Researchers at UT Southwestern Medical Center have developed a novel [...]
Vulnerability of Kidney Transplant Recipients to C. difficile Infection
A review highlighted kidney transplant recipients’ vulnerability to Clostridioides [...]
C. difficile: Challenges and Emerging Therapies
Clostridioides difficile infection (CDI) is a leading cause of healthcare-associated [...]
C. difficile in Nosocomial Settings: Challenges and Emerging Therapies
A review provided an in-depth overview of Clostridioides difficile [...]
Understanding C. difficile in Pediatrics: Challenges and Emerging Therapies
Clostridioides difficile infection (CDI) is a significant healthcare-associated pathogen primarily [...]
Study Reveals High Malnutrition Risk in Patients With Inflammatory Bowel Disease
Researchers of a study found high malnutrition risk in [...]
Study Reveals Link Between Inflammatory Bowel Disease Activity and Reduced Fertility in Women
Research has revealed a notable link between histological disease activity [...]
Patients With IBD at Higher Risk of Respiratory Syncytial Virus Infection, Study Shows
Researchers of a study presented at the American College of [...]
Gut Microbiota Key in Immune Therapy Side Effects
Researchers at the University of Michigan Health Rogel Cancer Center [...]
New Antibodies Targeting Various C. diff Strains: Insights
Researchers aimed to overcome the limited immunological tools available for [...]
Firmicutes’ Spore Formation and Role in C. diff Transmission
Researchers analyzed members of the firmicutes phylum, including those [...]
Study Reveals C. diff’s Role in Healthcare-Associated Diarrhea
Researchers of a recent study looked at Clostridioides difficile (C. [...]
C. difficile Infection: Pathogenesis and Treatment
A study analyzed Clostridioides difficile infection (CDI), a significant [...]
Phase 2b Study Shows Ritlecitinib and Brepocitinib Effective in Ulcerative Colitis Treatment
A phase 2b study on 317 patients found ritlecitinib and [...]
Study Reveals High Malnutrition Risk in IBD Patients, Underscores Need for Dietitian Support
A recent study found high malnutrition risk in 14% of [...]
Glycan Patterns on Antibodies May Lead to Non-Invasive IBD Blood Test
Researchers have identified unique glycan (sugar molecule) patterns on antibodies [...]
EMBL’s Key Discovery in XIAP/RIPK2 Complex Unlocks New IBD Treatments
EMBL Grenoble's Cusack group has made breakthroughs in understanding the [...]
FDA Approves Dabrafenib/Trametinib for BRAF V600E Tumors
The combination of dabrafenib and trametinib received accelerated FDA approval [...]
Study Reveals Sex Differences in GIST Outcomes
Research into sex differences in cancer has extended to gastrointestinal [...]
Phase 1 Study: Olverembatinib Shows Promise in SDH-Deficient GIST
Olverembatinib, an investigational tyrosine kinase inhibitor (TKI), has shown promising [...]
FDA Approves First Therapy for Indolent Systemic Mastocytosis, Avapritinib
The FDA approved avapritinib (Ayvakit) as the first and only [...]
Ulcerative Colitis Treatment Shows Promise in Mice, Combats Inflammation and Cancer
In a study using three mouse models, researchers developed a [...]
Glia Cells Linked to Enhanced Pain Sensitivity, Key in IBS Treatment
Michigan State University researchers discovered that glia cells in the [...]
Study Unveils “Reverse Metabolomics” for Inflammatory Bowel Disease
A study from the University of California San Diego introduces [...]
FDA Greenlights Mirikizumab: A Breakthrough in Ulcerative Colitis Treatment
A recent press release from Mount Sinai Health System announced [...]
Understanding TcdB Variants in C. difficile: Calcium’s Role in Infection Progression
Clostridioides difficile (C. difficile) produces TcdB, essential for its virulence [...]
Gut Microbiota’s Role in Immunotherapy
Researchers underscored the complex relationship between gut microbiota and [...]
Fecal Microbiota Transplant’s Effects on Cardiometabolic Health
A systematic review and meta-analysis explored the effect of [...]
Unique Mycobiota in C. difficile
A study focused on understanding the role of mycobiota, [...]
Diagnosing Clostridioides difficile Infection: Reference Assays to Alternative Strategies
Diagnosing Clostridioides difficile infection (CDI) presents several challenges. Two [...]
How Clostridioides difficile Toxin B Triggers Neurogenic Inflammation
Clostridioides difficile infection (CDI) is a significant cause of gastrointestinal [...]
Fecal Microbiota Transplantation Reduces Multidrug-Resistant Bacteria
Researchers focused on the global challenge posed by multidrug-resistant (MDR) [...]
Clostridioides difficile Infection Increases Risks for Kidney Transplant Recipients
In a study assessing the impact of Clostridioides difficile infection [...]
Researchers Develop XGBoost Model to Predict Imatinib Efficacy in GISTs
Researchers of a study focused on creating a model to [...]
Study Reveals TrkB Overexpression in GISTs Linked to Poor Prognosis
Researchers of a recent study examined the expression of trk [...]
Study Shows Surgery Improves Survival in Patients With GIST-SLM, Predictive Models Developed
In a recent study, researchers assessed the impact of surgical [...]
Advancing GIST Treatment: Focus on First-Line Options and Combination Therapies
The research on gastrointestinal stromal tumors (GISTs) has been focused [...]
Study Reveals ‘Chemo Brain’ in 64% of GIST Patients Following Treatment
In a study, approximately 64% of patients with gastrointestinal stromal [...]
Study Shows Hepatic Metastases and 51% 5-Year Survival Rate in Patients With Stage 4 GIST
Researchers of an analysis of stage 4 gastrointestinal stromal tumors [...]
Researchers Suggests Revising Follow-Up for Low-Risk GIST Patients to Balance Early Detection and Risks
In a cohort study, researchers analyzed the outcomes of guideline-based [...]
Study Finds Higher Cardiovascular Mortality Risk in Patients With Gastrointestinal Stromal Tumors
In a recent study, researchers evaluated the risks and predictors [...]
Lifetime Risks of C. Diff Infection Based on Insurance and Gender
Researchers analyzed claims data from 2011 to 2017 to [...]
Rising Antibiotic Resistance in C. Diff
A study looked at the escalating issue of antibiotic [...]
New Vaccines to Combat C. Diff
Researchers delved into the complex relationship between Clostridioides difficile’s [...]
Sporulation in Firmicutes and Its Impact on C. Diff Infections
A review analyzed the regulatory mechanisms that trigger the [...]
C. Diff: Virulence Factors and the Dual Role of Antibiotics
Researchers analyzed Clostridioides difficile, a leading cause of nosocomial [...]
Bezuclastinib Plus Sunitinib Shows Promise in Gastrointestinal Stromal Tumors
In part 1 of the phase 3 Peak trial, which [...]
Possible Safe and Effective Method for Challenging Gastric Gastrointestinal Stromal Tumors
Researchers of a study, published in the Journal of Surgical [...]
Companion Diagnostic for Avapritinib Use in Gastrointestinal Stromal Tumors Receives FDA Approval
The therascreen PDGFRA RGQ PCR kit was approved by the [...]
Bezuclastinib Found to Improve Symptoms in Patients With Nonadvanced Systemic Mastocytosis
In a study published at the 2023 American Society of [...]
Researchers Analyze the Incidence of Toxigenic Clostridioides Difficile in Infants
In a longitudinal cohort study, researchers aimed to examine [...]
Assessing the Composition of Fecal Microbiota as a Biomarker of Dietary Intake
Authors of a review article examined the probable use [...]
Examining Early-Life Stages of Clostridioides Difficile
In a review article, authors looked into the microbiome [...]
Exploring the Next Generation of Fecal Microbiota Transplantation
In dysbiosis-related diseases, fecal microbiota transplantation (FMT) has transpired [...]
Personalized Microbiome Treatments for Enhanced IBS Therapy
A study compared 942 IBS patients of different subtypes (diarrhea, [...]
IBS-C: Low-FODMAP Diet’s Long-Term Impact
Researchers reviewed the impact of fibers, functional foods, and probiotics [...]
Economic Status and Abdominal Pain: Link
For a recent study (the COMFORT study), researchers investigated the [...]
Differences in Amino Acid and Neurotransmitter Levels in FGID Patients
Researchers analyzed the plasma concentration differences of 19 proteogenic and [...]
Exploring Personalized Pharmacologic Approaches in Treating IBS
Dr. Lin Chang welcomes Dr. Anthony Lembo, a specialist [...]
Sucrase-Isomaltase Deficiency in Patients with Presumed IBS-D/M
A study aimed to investigate the prevalence of sucrase-isomaltase deficiency [...]
Key MicroRNAs and Pathways Behind Visceral Hypersensitivity in IBS-D Patients
Researchers sought to uncover the epigenetic mechanism underlying visceral [...]
Prevalence of Organic Diseases in IBS Patients Undergoing Colonoscopy
Researchers conducted a meta-analysis to determine the prevalence of organic [...]
Patients With Fibromyalgia and Irritable Bowel Syndrome Have Lower Outcomes and Higher Opioid Usage and Cost After Shoulder and Elbow Surgery
Researchers of a recent study investigated the relationship between [...]
Exploring Beyond the Low-FODMAP Diet: Promising Dietary Strategies for Managing Irritable Bowel Syndrome (IBS)
Researchers reviewed the current evidence on the diet-microbiota interaction [...]
New Treatment Guidelines for IBS-D
Researchers analyzed the significance of irritable bowel syndrome (IBS) [...]
Fiber and Gut Bacteria in Managing Irritable Bowel Syndrome with Constipation
Researchers investigated the impact of various nutritional components like [...]
Altered Gut Microbiota and Symptom Exacerbation: Insights into Irritable Bowel Syndrome
Researchers investigated the role of gastrointestinal microbiota in the [...]
Investigating the Brain-Gut-Microbiome Connection: Insights for Irritable Bowel Syndrome
Researchers investigated the alterations in the brain-gut-microbiome system (BGM) [...]
Link Between Gut Microbiota and Abdominal Pain and Bloating in IBS-D Patients
Researchers investigated the relationship between the efficacy of probiotics [...]
Link Between Gut Symptoms and Vitamin D, Serotonin, and Neurotrophic Factor Levels in IBS-D Patients
A recent study investigated the relationship between gastrointestinal (GI) [...]
Sex-Bias in IBS: Linking Steroids to the Gut-Brain Axis
Women experience irritable bowel syndrome (IBS) more than men, [...]
Good Microbes, Bad Genes? Antimicrobial Resistance in the Human Microbiome
Antimicrobial resistance is a major global health threat. Researchers [...]
Identification of Shared and Disease-Specific Host Gene
The way the gut microbiome and host gene regulation [...]
Gut Microbial β-glucuronidases Are Depleted in IBS
Hypersensitivity in the gut is common in irritable bowel [...]
Mast Cell Mediation of Visceral Sensation and Permeability in IBS
Irritable bowel syndrome (IBS) symptoms may be formed from [...]
