In a recent study, researchers assessed the impact of surgical resection on survival in patients with gastrointestinal stromal tumors synchronous liver metastasis (GIST-SLM) to develop predictive models for overall survival (OS) and cancer-specific survival (CSS). Kaplan-Meier analysis revealed significant differences in 1, 3, and 5-year OS and CSS rates. Additionally, patients who underwent surgery combined with targeted therapy exhibited better OS and CSS at these intervals than those who had surgery alone. Nomograms were developed to predict 1, 3, and 5-year OS and CSS, demonstrating good predictive accuracy with area under the curve values and C-indexes, indicating strong model performance.
The researchers concluded that surgical treatment significantly improved both OS and CSS in patients with GIST-SLM. It also suggested that the combination of surgery and chemotherapy may offer enhanced long-term survival benefits. The constructed nomograms for predicting 1, 3, and 5-year OS and CSS were validated internally, showing good consistency. These models are expected to assist in clinical management and help optimize treatment strategies for patients with GIST-SLM, providing a valuable tool for predicting patient outcomes and guiding treatment decisions.
Reference: Liu L, Xia X, Ju Y, et al. Effects of surgical management for gastrointestinal stromal tumor patients with liver metastasis on survival outcomes. Front Oncol. 2024;14:1289885. doi: 10.3389/fonc.2024.1289885.
Link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10860711/
