Researchers analyzed the connection between gut dysbiosis and psoriasis, suggesting that imbalances in gut bacteria may contribute to the development of psoriasis. Researchers propose probiotic supplements and fecal microbiota as potential preventive and therapeutic approaches for psoriasis patients. The interaction between gut microbiota and the host is primarily mediated by bacteria-produced metabolites, which play a role in the immune system. The study also reviewed recent literature on these metabolites, emphasizing their significance in immune functions, particularly in the context of psoriasis and its common comorbidity, psoriatic arthritis.

Reference: Lai Y, Wu X, Chao E, Bloomstein JD, Wei G, Hwang ST, Shi Z. Impact of Gut Bacterial Metabolites on Psoriasis and Psoriatic Arthritis: Current Status and Future Perspectives. J Invest Dermatol. 2023 Sep;143(9):1657-1666. doi: 10.1016/j.jid.2023.05.012. Epub 2023 Jul 9. PMID: 37422760.

Link: https://pubmed.ncbi.nlm.nih.gov/37422760/