A study published in PLoS One aimed to assess the impact of chronic obstructive pulmonary disease (COPD) on mortality and neurologic outcomes in adults with in-hospital cardiac arrest (IHCA).

The study comprised 593 consecutive hospitalized patients with IHCA undergoing advanced cardiovascular life support (ACLS)–guided resuscitation from 2012 to 2018. In the population of interest, 27.3% had COPD while 72.7% did not. The primary and secondary outcomes of interest were survival to discharge and favorable neurological outcome.

The researchers observed that patients with COPD were on average older, more often female, and had higher Charlson Comorbidity scores. Location of cardiac arrest, initial rhythm, duration of cardiopulmonary resuscitation, and rates of defibrillation and return of spontaneous circulation were similar in both groups. Also, patients with COPD had significantly lower rates of both survival to discharge (10.5% vs. 21.6%, P = 0.002) and favorable neurologic outcomes (7.4% vs. 15.9%, P = 0.007). Analysis showed that COPD was independently associated with lower rates of survival to discharge (odds ratio = 0.54, 95% confidence interval 0.30-0.98, P = 0.041).

“In this contemporary prospective registry of adults with IHCA, COPD was independently associated with significantly lower rates of survival to discharge,” the researchers concluded.

Keywords:  COPD, biomarkers, prognosis, readmission


Link: https://pubmed.ncbi.nlm.nih.gov/34843511/