People who are pre-disposed to insomnia have a higher chance of suffering from migraines, according to a study published in Pharmacogenomics and Personalized Medicine.

In this case-control study, researchers used bidirectional mendelian randomization (MR) analysis to discern the relationship between insomnia and migraine. Variables for insomnia were derived from the largest genome-wide association study of 1,331,010 participants, while the genetic instruments for migraine derived from the largest meta-analysis of migraine with 59,674 cases. Findings were compared with a control arm of 316,078 individuals.

According to the results, subjects with insomnia had a markedly higher risk of migraine (odds ratio [OR], 4.29; 95% confidence interval [CI], 3.21-5.74; P<0.001), compared with those without insomnia. The researchers further observed from the bidirectional two-sample MR analysis that insomnia was significantly associated with an augmented risk of migraine (OR, 1.24; 95% CI, 1.11-1.38; P=1.01×10-4).

“Conclusively, our study highlighted that increased migraine risk was confined to subjects with a genetic pre-disposition to insomnia, and these findings had potential implications for improving the sleep quality to reduce the burden of migraine,” the researchers concluded.



Keywords: case–control, insomnia, mendelian randomization, migraine