A study published in Clinical and Experimental Dermatology sought to identify a combination of biomarkers that allow for a better differentiation between neutrophilic dermatoses.
Biopsies were obtained from patients with normal skin (NS, n=4), chronic plaque psoriasis (PSO, n=7), paradoxical psoriasis (PP, n=8), generalized pustular psoriasis (GPP, n=9), subcorneal pustular dermatosis of Sneddon-Wilkinson (SPD, n=3), acute generalized exanthematous pustulosis (AGEP, n=3), hidradenitis suppurativa (HS, n=7), Sweet syndrome (SS, n=8), and pyoderma gangraenosum (PG, n=8).
Three biomarkers were obsessed: IL-17E, iNOS, and Arginase1, each in combination with MPO and CD68, to identify neutrophils and macrophages, respectively.
The researchers reported that the neutrophil infiltrate was helpful to differentiate between PP (high density), and PSO (low density). Mature neutrophils and pro-inflammatory macrophages were readily detectible in PP, PG, and SPD, while immature neutrophils and macrophages were more common in GPP, AGEP, HS, and SS.
Additionally, SS was associated with a high expression of IL-17E and iNOS in the epidermis while PG exhibited low expression rates. High Arginase1 expression in the granular epidermis was associated with SPD.
Link: Clinical and Experimental Dermatology https://onlinelibrary.wiley.com/doi/10.1111/ced.14988