Using data from the BIOBADADERM registry from October 2008 to December 2021, researchers sought to determine the differences between generalized pustular psoriasis (GPP) and plaque psoriasis (PP). A total of 3,864 patients had PP, 41 patients had GPP, and 294 patients had palmoplantar pustular psoriasis (PPP). Patients with GPP were older and had a greater rate of chronic hepatic disease and renal failure vs patients with PP. Those who had PPP had less disease duration at first and had less intake of alcohol. PPP was also associated with older age, more women, history of smoking, and hypercholesterolemia. In all of the groups, biologic drugs were the most commonly prescribed systemic drug. A US study saw that, in 95 patients with GPP, the most frequently recognized comorbidities were hypertension, depression, diabetes, chronic kidney disease, and hypothyroidism. Through their analysis, researchers concluded that in comparing patients with PP, GPP was associated with a greater prevalence of hepatic and renal disease, and PPP was associated with greater prevalence of hypercholesterolemia. They noted that future studies should confirm their findings, as the results may influence disease management.

Reference: Ruiz Genao DP, Carretero G, Rivera-Diaz R, et al. Differences in epidemiology, comorbidities and treatment choice between plaque psoriasis and pustular psoriasis: results from the BIOBADADERM registry. Br J Dermatol. 2022;187(5):817-820. doi:10.1111/bjd.21763