A systematic review and meta-analysis evaluated the prevalence of acne vulgaris among women with polycystic ovary syndrome (PCOS) across 95 cross-sectional studies. Using PRISMA and MOOSE guidance, researchers searched major international databases through January 2025 and included studies that used established diagnostic criteria for PCOS and reported acne prevalence. The pooled prevalence of acne among women with PCOS was 49%, though the estimate was revised downward to 37% after trim-and-fill adjustment for publication bias. Substantial heterogeneity was observed across studies, likely reflecting differences in diagnostic criteria, population characteristics, study methods, and geographic settings.
Subgroup analyses showed wide regional variation, with acne prevalence ranging from 32% in Europe to 76% in Oceania. Acne was most common among adolescents younger than 18 years, followed by women aged 18-30 years, and those older than 30 years. Prevalence also varied by PCOS diagnostic criteria, publication year, BMI, and acne severity. The authors concluded that acne is a common clinical manifestation of PCOS and emphasized the need for standardized diagnostic criteria, early detection, and holistic management that considers age, lifestyle, diet, physical activity, metabolic health, and psychological well-being. They also noted future studies with stronger methodology and longitudinal designs are needed to better clarify the relationship between PCOS and acne.
Reference: Pourahmad B, Majidnia M, Saniee N, et al. Prevalence of Acne Vulgaris Among Women with Polycystic Ovary Syndrome: A Systematic Review and Meta-Analysis. Med J Islam Repub Iran. 2025 Aug 11;39:105. doi: 10.47176/mjiri.39.105. PMID: 41089626; PMCID: PMC12516454.
